Effects of cocaine
Cocaine is a very powerful drug, capable of significantly altering the psychophysiological state of the consumer. Throughout the history of coca has been used as an invigorating fitness. The ability of cocaine to reduce hunger and fatigue and stimulate muscle activity has been widely recognized. It has been suggested that this effect is due to the consequent increase in blood acidity, from uric acid, and stimulation of the degradation of carbohydrates for energy in the tissues. Even assuming that this metabolic action occurs, the effect on the consumer still depends on many factors. As with any drug, the effects of a minimum dose vary with the particular mental and physical well-being of consumers.
Stimulation is much deeper if the individual is below normal, you feel tired or hungry. The effects are minimal if present the normal euphoria associated with good health. Cocaine has been shown to have a positive effect on muscle activity in general and, more specifically, reaction time and muscle strength.
Researchers have been unable to demonstrate any direct effect of cocaine on motor nerves or muscle groups, hence, have concluded that their effect is probably indirect, acting to increase the overall sense of well-being and willingness to work .
Pharmacologically, cocaine produces two different and unrelated actions:
First it acts as a local anesthetic. After local application, cocaine blocks the conduction of impulses in nerve fibers for about 20 to 40 minutes due to its ability to interfere with the movement of sodium ions across the nerve cell.
Second is a powerful central nervous system stimulant. This effect begins in the sympathetic nervous system cortical, probably due to competitive blockade of norepinephrine reuptake back into the adrenergic fiber.
The action on the central nervous system that produces euphoria and excitement, is the main motivator for the use of cocaine. This reinforces the most expensive drug initiative and achievement aspirations to provide consumers with more energy and optimism. Psychologically, cocaine causes increased heart and respiratory rates, elevated body temperature and blood pressure, blood vessel constriction and dilation of the pupils.
Since cocaine is short acting, can be used repeatedly, and take in one day excessive amounts (more than 10 grams). The lethal dose is approximately 1.2 grams (1200 mg.) For most individuals, if taken at once. Death, in this case is due to respiratory failure, although it occurs rarely. Large doses or chronic use can cause anxiety, hallucinations, impotence, insomnia, create a sense of mental and muscular strength as well as visual hallucinations, auditory and tactile.
The paranoid delusions, combined with excessive sense of personal power, can make a person who consumes large doses, especially injection, a very antisocial and dangerous. Occur frequently rapid changes in perception, it dulls the trial, there is a release of inhibitions, and are characteristic of those who abuse cocaine aggression, panic reactions and, over time, agitated depression.
Despite establishing a strong psychological dependence to cocaine, this drug does not cause physical dependence. No withdrawal or withdrawal symptoms occur when the drug is withdrawn. Due to the rapid metabolism of cocaine, large amounts can be administered in relatively short periods. It is generally considered that this drug does not create tolerance, although this point remains debated by several investigators. Despite the possible absence of physical tolerance or dependence, this drug is characterized by a strong tendency for consumers to continue using. Induces a high level of psychological dependence and often results in a destructive kind of abuse. This pattern is often difficult to understand since many casual users do not report adverse effects, need for drugs, or addiction.
However, there are voluminous reports of abuse that follow this general pattern: shortly after the drug is administered to a loss of sensation in the mouth and often have no sense of language. A pleasant feeling of warmth throughout the body is followed by a growing sense of excitement. The consumer feels strong and lively, capable of taking any action. The consumer feels strong and lively, capable of taking any action. Fatigue is reduced and often experience pleasant feelings of wealth and power.
This sense of elation lasts from 45 minutes to 2 hours, depending on the quality of the cocaine and the degree has been lowered As the effects wear off, it is usually depression and fatigue. Headache and discomfort often produce a strong desire to rise again. It is therefore difficult to understand the desire to continue using it, although it is believed physiological dependence (1). But again, as in the case of other drugs, how to use cocaine depends on the individual. Some people use it occasionally with favorable results, while others are trapped in a vicious cycle of abuse.